Περίληψη:
The aim was to investigate the association between pre-diagnostic
intakes of polyphenol classes (flavonoids, lignans, phenolic acids,
stilbenes, and other polyphenols) in relation to breast cancer survival
(all-cause and breast cancer-specific mortality). We used data from the
European Prospective Investigation into Cancer and Nutrition cohort.
Pre-diagnostic usual diet was assessed using dietary questionnaires, and
polyphenol intakes were estimated using the Phenol-Explorer database. We
followed 11,782 breast cancer cases from time of diagnosis until death,
end of follow-up or last day of contact. During a median of 6 years,
1482 women died (753 of breast cancer). We related polyphenol intake to
all-cause and breast cancer-specific mortality using Cox proportional
hazard models with time since diagnosis as underlying time and strata
for age and country. Among postmenopausal women, an intake of lignans in
the highest versus lowest quartile was related to a 28 % lower risk of
dying from breast (adjusted model: HR, quartile 4 vs. quartile 1, 0.72,
95 % CI 0.53; 0.98). In contrast, in premenopausal women, a positive
association between lignan intake and all-cause mortality was found
(adjusted model: HR, quartile 4 vs. quartile 1, 1.63, 95 % CI 1.03;
2.57). We found no association for other polyphenol classes. Intake of
lignans before breast cancer diagnosis may be related to improved
survival among postmenopausal women, but may on the contrary worsen the
survival for premenopausal women. This suggests that the role of
phytoestrogens in breast cancer survival is complex and may be dependent
of menopausal status.
Συγγραφείς:
Kyro, Cecilie
Zamora-Ros, Raul
Scalbert, Augustin and
Tjonneland, Anne
Dossus, Laure
Johansen, Christoffer and
Bidstrup, Pernille Envold
Weiderpass, Elisabete
Christensen,
Jane
Ward, Heather
Aune, Dagfinn
Riboli, Elio
His,
Mathilde
Clavel-Chapelon, Francoise
Baglietto, Laura
Katzke,
Verena
Kuehn, Tilman
Boeing, Heiner
Floegel, Anna and
Overvad, Kim
Lasheras, Cristina
Travier, Noemie
Sanchez,
Maria-Jose
Amiano, Pilar
Chirlaque, Maria-Dolores
Ardanaz,
Eva
Khaw, Kay-Tee
Wareham, Nick
Perez-Cornago, Aurora and
Trichopoulou, Antonia
Lagiou, Pagona
Vasilopoulou, Effie and
Masala, Giovanna
Grioni, Sara
Berrino, Franco
Tumino,
Rosario
Sacerdote, Carlotta
Mattiello, Amalia and
Bueno-de-Mesquita, H. B(as).
Peeters, Petra H.
van Gils, Carla
and Borgquist, Signe
Butt, Salma
Zeleniuch-Jacquotte, Anne and
Sund, Malin
Hjartaker, Anette
Skeie, Guri
Olsen, Anja and
Romieu, Isabelle
