Τίτλος:
A systems BIOlogy Study to TAilored Treatment in Chronic Heart Failure:
rationale, design, and baseline characteristics of BIOSTAT-CHF
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
AimsDespite major improvements in pharmacological and device treatments,
heart failure remains a syndrome with high morbidity and mortality, poor
quality of life, and high health-care costs. Given the extensive
heterogeneity among patients with heart failure, substantial differences
in the response to therapy can be expected. We hypothesize that
individualized therapy is an essential next step to improve outcomes in
patients with heart failure.
MethodsThe BIOlogy Study to TAilored Treatment in Chronic Heart Failure
(BIOSTAT-CHF) included 2516 patients with worsening signs and/or
symptoms of heart failure from 11 European countries, who were
considered to be on suboptimal medical treatment. Another 1738 patients
from Scotland were included in a validation cohort. Overall, both
patient cohorts were well matched. The majority of patients were
hospitalized for acute heart failure, and the remainder presented with
worsening signs and/or symptoms of heart failure at outpatient clinics.
Approximately half of the patients were in New York Heart Association
class III, and 7% vs 34% of patients of the index vs validation cohort
had heart failure with preserved ejection fraction. According to study
design, all patients used diuretics, but owing to the inclusion criteria
of both cohorts, patients were not on optimal, evidence-based medical
therapy. In the follow-up phase, uptitration to guideline-recommended
doses was encouraged.
ConclusionBy using a novel systems biology approach, incorporating
demographics, biomarkers, genome-wide analysis, and proteomics, a model
that predicts response to therapy will be developed, which should be
instrumental in developing alternative therapies for patients with
suboptimal response to currently recommended therapies and thus further
improve care for patients with heart failure.
Συγγραφείς:
Voors, Adriaan A.
Anker, Stefan D.
Cleland, John G. and
Dickstein, Kenneth
Filippatos, Gerasimos
van der Harst, Pim and
Hillege, Hans L.
Lang, Chim C.
ter Maaten, Jozine M.
Ng,
Leong
Ponikowski, Piotr
Samani, Nilesh J.
van Veldhuisen,
Dirk J.
Zannad, Faiz
Zwinderman, Aeilko H.
Metra, Marco
Περιοδικό:
European Journal of Heart Failure
Λέξεις-κλειδιά:
Heart failure; Individualized treatment; Treatment response; Systems
biology
