Περίληψη:
Chronic lymphocytic leukemia (CLL) has few known modifiable risk
factors. Recently, circadian disruption has been proposed as a potential
contributor to lymphoid neoplasms’ etiology. Serum melatonin levels have
been found to be significantly lower in CLL subjects compared with
healthy controls, and also, CLL prognosis has been related to
alterations in the circadian molecular signaling. We performed the first
investigation of an association between night shift work and CLL in 321
incident CLL cases and 1728 population-based controls in five areas of
Spain. Participants were interviewed face-to-face by trained
interviewers to collect information on sociodemographic factors,
familial, medical and occupational history, including work shifts and
other lifestyle factors. We used logistic regression models adjusted for
potential confounders to estimate odds ratios (OR) and 95% confidence
intervals (CI). Seventy-nine cases (25%) and 339 controls (20%) had
performed night work. Overall, working in night shifts was not
associated with CLL (OR=1.06; 95% CI=0.78-1.45, compared with day
work). However, long-term night shift (>20 years) was positively
associated with CLL (OR(tertile 3 (vs. day-work))=1.77; 95%=1.14-2.74),
although no linear trend was observed (P trend=0.18). This association
was observed among those with rotating (OR(tertile 3 (vs.
day-work))=2.29; 95% CI=1.33-3.92; P trend=0.07), but not permanent
night shifts (OR(tertile 3 (vs. day-work)) = 1.16; 95% CI=0.60-2.25; P
trend=0.86). The association between CLL and long-term rotating night
shift warrants further investigation.
Συγγραφείς:
Costas, Laura
Benavente, Yolanda
Olmedo-Requena, Rocio and
Casabonne, Delphine
Robles, Claudia
Gonzalez-Barca, Eva-Maria
and de la Banda, Esmeralda
Alonso, Esther
Aymerich, Marta and
Tardon, Adonina
Marcos-Gragera, Rafael
Gimeno-Vazquez, Eva and
Gomez-Acebo, Ines
Papantoniou, Kyriaki
Castano-Vinyals, Gemma
and Aragones, Nuria
Pollan, Marina
Kogevinas, Manolis
de
Sanjose, Silvia
