Τίτλος:
Modeling and administration scheduling of fractional-order
pharmacokinetic systems
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Fractional-order dynamical systems were recently introduced in the field
of pharmacokinetics where they proved powerful tools for modeling the
absorption, disposition, distribution and excretion of drugs which are
liable to anomalous diffusion, deep tissue trapping and other nonlinear
phenomena. In this paper we present several ways to simulate such
fractional order pharmacokinetic models and we evaluate their accuracy
and complexity on a fractional order pharmacokinetic model of
Amiodarone, an anti-arrhythmic drug. We then propose an optimal
administration scheduling scheme and evaluate it on a population of
patients. (C) 2017, IFAC (International Federation of Automatic Control)
Hosting by Elsevier Ltd. All rights reserved.
Συγγραφείς:
Herceg, Domagoj
Ntouskas, Sotiris
Sopasakis, Pantelis and
Dokoumetzidis, Aris
Macheras, Panos
Sarimveis, Haralambos and
Patrinos, Panagiotis
Περιοδικό:
IFAC-PapersOnLine
Λέξεις-κλειδιά:
Fractional-order systems; Pharmacokinetics; Drug administration
DOI:
10.1016/j.ifacol.2017.08.2178
