Τίτλος:
Biomarkers Guided Treatment Strategies in Adult Patients with Asthma:
Ready for the Clinical Field?
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Asthma is a chronic inflammatory airways disorder mainly characterized
by heterogeneity. In the more severe forms, a discordance often exists
between symptoms and inflammation. Difficulty in managing asthma derives
partly from the multiple phenotypes existing and our inability to
recognize them. The use of non-invasive, with main representative the
fraction of exhaled nitric oxide, or semi-invasive techniques such as
induced sputum are effective tools that can help us to guide asthma
treatment. In the latest years, several serum biomarkers related to
asthmatic inflammation have been used for the better recognition of
asthma sub-phenotypes to achieve optimization of therapy and disease
outcome. In patients with mild-moderate asthma, as well as patients with
more severe asthma, the use of blood eosinophils revealed an acceptable
accuracy for the prediction of airway eosinophilia indicating that in
future studies may facilitate both individualized treatment and
management of asthma. None of the above techniques have been
incorporated in clinical practice although sputum eosinophils can be
used in patients with severe asthma particularly in specialized centers
with great experience. Of great interest are blood eosinophils since
current data support their role either as tool for treatment selections
or/and as a biomarker of airway eosinophilia.
Συγγραφείς:
Tsilogianni, Zoi
Ntontsi, Polyxeni
Papaioannou, Andriana I. and
Bakakos, Petros
Loukides, Stelios
Περιοδικό:
Archivum Immunologiae et Therapiae Experimentalis
Εκδότης:
SPRINGER BASEL AG
Λέξεις-κλειδιά:
Asthma; Biomarkers; Treatment; Strategy; Eosinophils; Sputum
DOI:
10.1007/s00005-016-0407-9
