Περίληψη:
Giant cell tumor (GCT) of bone is a locally aggressive benign neoplasm
that is associated with a large biological spectrum ranging from latent
benign to highly recurrent and occasionally metastatic malignant bone
tumor. It accounts for 4-10% of all bone tumors and typically affects
the meta-epiphyseal region of long bones of young adults. The most
common site involved is the distal femur, followed by the distal radius,
sacrum, and proximal humerus. Clinical symptoms are nonspecific and may
include local pain, swelling, and limited range of motion of the
adjacent joint. Radiographs and contrast-enhanced magnetic resonance
imaging (MRI) are the imaging modalities of choice for diagnosis.
Surgical treatment with curettage is the optimal treatment for local
tumor control. A favorable clinical outcome is expected when the tumor
is excised to tumor-free margins, however, for periarticular lesions
this is usually accompanied with a suboptimal functional outcome. Local
adjuvants have been used for improved curettage, in addition to
systematic agents such as denosumab, bisphosphonates, or interferon
alpha. This article aims to discuss the clinicopathological features,
diagnosis, and treatments for GCT of bone.
Συγγραφείς:
Mavrogenis, Andreas F.
Igoumenou, Vasileios G.
Megaloikonomos,
Panayiotis D.
Panagopoulos, Georgios N.
Papagelopoulos,
Panayiotis J.
Soucacos, Panayotis N.
