Περίληψη:
Appendiceal neuroendocrine neoplasms (ANEN) are mostly discovered
coincidentally during appendicectomy and usually have a benign clinical
course; thus, appendicectomy alone is considered curative. However, in
some cases, a malignant potential is suspected, and therefore additional
operations such as completion right hemicolectomy are considered. The
existing European Neuroendocrine Tumour Society (ENETS) guidelines
provide useful data about epidemiology and prognosis, as well as
practical recommendations with regards to the risk factors for a more
aggressive disease course and the indications for a secondary operation.
However, these guidelines are based on heterogeneous and retrospective
studies. Therefore, the evidence does not seem to be robust, and there
are still unmet needs in terms of accurate epidemiology and overall
prognosis, optimal diagnostic and follow-up strategy, as well as
identified risk factors that would indicate a more aggressive surgical
approach at the beginning and a more intense follow-up. In this review,
we are adopting a critical approach of the ENETS guidelines and
published series for ANEN, focusing on the above-noted grey areas.
Συγγραφείς:
Toumpanakis, Christos
Fazio, Nicola
Janson, Eva Tiensuu and
Horsch, Dieter
Pascher, Andreas
Reed, Nicholas
O'Toole,
Dermot
van Dijkum, Els Nieveen
Partelli, Stefano
Rinke, Anja
and Kos-Kudla, Beata
Costa, Frederico
Pape, Ulrich-Frank and
Grozinsky-Glasberg, Simona
Scoazec, Jean-Yves
Detlef, Bartsch
and Rudolf, Arnold
Eric, Baudin
Lisa, Bodei
Ivan, Borbath
and Jaume, Capdevila
Martyn, Caplin
Jie, Chen
Frederico,
Costa
Anne, Couvelard
Jaroslaw, Cwikla B.
de Herder, Wouter
W.
Massimo, Falconi
Jenny, Falkerby
Nicola, Fazio
Diego,
Ferone
Andrea, Frilling
Rocio, Garcia-Carbonero
Simona,
Glasberg
Vera, Gorbunova
Ashley, Grossman
Dieter, Hoersch
and Robert, Jensen
Gregory, Kaltsas
Guenter, Kloeppel
Peter,
Knigge Ulrich
Beata, Kos-Kudla
Guenter, Krejs J.
Eric,
Krenning
Matthew, Kulke
Steven, Lamberts W. J.
Elisabeth,
Nieveen van Dijkum
Juan Manuel, O'Connor
Dermot, O'Toole and
Ulrich-Frank, Pape
Stefano, Partelli
Ellen, Pavel Marianne and
Marc, Peeters
John, Ramage
Nicholas, Reed
Guido, Rindi and
Anja, Rinke
Philippe, Ruszniewski
Halfdan, Sorbye
Anders,
Sundin
Jean-Yves, Scoazec
Babs, Taal G.
Eva, Tiensuu Janson
and Christos, Toumpanakis
Juan, Valle
Marie-Pierre, Vullierme
and Staffan, Welin
Bertram, Wiedenmann
ENETS 2016 Munich
Advisory Board
