Περίληψη:
Salivary gland adenocarcinoma not otherwise specified (NOS) is a
malignant epithelial tumor composed of ductal/glandular structures with
or without cystic formation. Histologically it is classified as high
grade with relevant biological behavior. Although both minor and major
glands may be involved, the majority (60%) implicate the parotid gland.
Location, regional lymph node status, and histological grade are some of
the factors that predict the progress of the disease and the development
of metastases. Long follow-up is considered the standard option as
distant metastases (DM) may occur despite regional control. Primary
sites of DM, besides lymph nodes, include bone, lung, and liver. Herein
we report a unique case of a 68-year-old female with a previous history
of high-grade adenocarcinoma NOS of her right parotid gland. On her
biannual follow-up examination, MRI revealed an abnormal increase in the
size of a known uterine leiomyoma of the posterior uterine wall.
Positron emission tomography-CT (PET-CT) showed increased uptake in the
uterus and lungs. On frozen section, adenocarcinoma was found at the
center of the leiomyoma. Histological and immunohistochemical findings
were consistent with secondary involvement by the salivary gland
adenocarcinoma NOS. Treatment consisted of cyclophosphamide, adriamycin,
and cisplatin with poor outcome. The patient was lost to follow-up.
Review of the literature indicates that no similar case has been
reported in the English literature.
Συγγραφείς:
Psarris, Alexandros
Koufopoulos, Nektarios
Grivas, Anastasios
and Papatheodorou, Dimitrios C.
Khaldi, Lubna
