Τίτλος:
Opioid-Free Anesthesia and Postoperative Cognitive Dysfunction After Minor Urological Surgery: A Case Series Study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Postoperative cognitive dysfunction (POCD) is a complication that mainly occurs in adult patients and refers to a new-onset decline in cognitive function after anesthesia and surgery. The literature lacks evidence regarding opioid-free anesthesia and its impact on mental function postoperatively. Objectives: The effect of opioid-free anesthesia on POCD following urological surgery has not been previously reported. Accord-ingly, we present a case series of 15 adult patients undergoing transurethral urological surgery under general anesthesia using an opioid-free protocol with dexmedetomidine, ketamine, and lidocaine. Methods: Patients that underwent simple transurethral elective urological procedures under general opioid-free anesthesia were included. This case series is part of a prospective clinical study regarding opioid-free anesthesia and served as a pilot sample. The mini-mental state examination (MMSE) test, performed preoperatively and 12 hours postoperatively, was applied to assess POCD. Results: Fifteen patients with a mean age of 68 years old were included in the study. The opioid-free protocol was associated with non-statistically significant changes of the MMSE test after minor urological procedures. Conclusions: In our study, an opioid-free protocol of general anesthesia, using a mixture of dexmedetomidine, ketamine, and lido-caine, did not seem to have a negative impact on postoperative cognitive function in patients undergoing transurethral urological surgery. Further studies specifically designed to identify this effect are certainly required to further prove such an effect. © 2022, Author(s).
Συγγραφείς:
Efstathiou, G.
Batistaki, C.
Soulioti, E.
Roungeris, L.
Matsota, P.
Περιοδικό:
Anesthesiology and Pain Medicine
Εκδότης:
Kowsar Medical Institute
Λέξεις-κλειδιά:
dexaton; dexmedetomidine; ketamina molteni; ketamine; lidocaine; paracetamol; propofol; ranitidine; rocuronium, adult; aged; anesthesia; anesthesiologist; Article; bispectral index; bladder tumor; case report; clinical article; continuous infusion; drug withdrawal; education; extubation; female; human; lithotripsy; male; Mini Mental State Examination; opioid free anesthesia; perioperative period; postoperative cognitive dysfunction; prospective study; transurethral resection; urologic surgery
