Three component Kabachnik-Fields condensation leading to substituted aminomethane-P-hydroxymethylphosphonic acids as atool for screening of bacterial urease inhibitors

Vassiliou, S.; Grabowiecka, A.; Kosikowska, P.; Berlicki, L.

doi:10.3998/ark.5550190.0013.404

Three component Kabachnik-Fields condensation leading to substituted aminomethane-P-hydroxymethylphosphonic acids as atool for screening of bacterial urease inhibitors

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3067201 15 Αναγνώσεις

Περιγραφή
Περιεχόμενα

Μονάδα:

Ερευνητικό υλικό ΕΚΠΑ

Τίτλος:

Three component Kabachnik-Fields condensation leading to substituted aminomethane-P-hydroxymethylphosphonic acids as atool for screening of bacterial urease inhibitors

Γλώσσες Τεκμηρίου:

Αγγλικά

Περίληψη:

Condensation of hydroxyalkane-H-phosphinic acids, formaldehyde and secondary amines has given entry to the synthesis of variously substituted aminomethane-P-hydroxymethylphosphinic acids. The proposed strategy allowed to perform a feasible synthesis of several molecules with designed biological activity towards bacterial urease - an enzyme which is a medicinally relevant molecular target. The inhibitory potency of compounds was validated using enzyme purified from Bacillus pasteurii. © ARKAT-USA, Inc.

Έτος δημοσίευσης:

2012

Συγγραφείς:

Vassiliou, S.
Grabowiecka, A.
Kosikowska, P.
Berlicki, L.

Περιοδικό:

ARKIVOC: Online Journal of Organic Chemistry

Τόμος:

2012

Αριθμός / τεύχος:

Σελίδες:

33-43

Επίσημο URL (Εκδότης):

https://doi.org/10.3998/ark.5550190.0013.404

DOI:

10.3998/ark.5550190.0013.404

Μόνιμη διεύθυνση:

https://pergamos.lib.uoa.gr/uoa/dl/object/3067201

Three component Kabachnik-Fields condensation leading to substituted aminomethane-P-hydroxymethylphosphonic acids as atool for screening of bacterial urease inhibitors

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